With the win, Towson improved its overall record to 3-2, its best mark after five games since the start of the 2008-09 season when the Tigers also started 3-2.
The 39-point margin of victory Monday was Towson's largest since a 122-58 win over Buffalo on March 7, 1992.
Junior Mike Burwell led four Tigers in double figures with 18 points. The guard scored in double figures for the second consecutive game, netting three three-point field goals in each contest.
Graduate student Bilal Dixon registered his second double-double of the season with 10 points on 5-for-6 shooting and a game-high 11 rebounds. The forward/center added six blocked shots to his stat line in just 22 minutes of action.
Junior Marcus Damas (12) and sophomore Kris Walden (10) also scored in double digits, while junior Jerrelle Benimon posted nine points and grabbed seven rebounds in 21 minutes.
For the third straight game, Towson got off to a hot start and led 7-0 after a Jerome Hairston jumper four minutes into the game.
Leading 16-11 midway through the opening period, Towson tallied 13 of the next 17 points and the Tigers led by 20 at halftime.
Towson scored the first seven points of the second half to go up 46-19 and the Tigers led by as many as 42 in the second half. Towson held Cincinnati Christian to just five second half field goals in a dominating defensive effort.
The Tigers shot 56.6 percent from the field and won the rebounding battle for the fourth straight game, 46-22. Towson held the Eagles to just 16.7 percent shooting in the second half and 24.1 percent for the game.
All 13 Tigers played in the game, with 12 of them scoring
Towson will return to action on Monday, Nov. 26 at local rival Loyola. Tip time from Reitz Arena in Baltimore is set for 7 p.m.